Concomitant Use of Antipsychotics and Diuretic Accelerates the Hyponatremia Effect

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  • Nurazah Ismail Psychiatry Unit, Faculty of Medicine and Health Science, Universiti Sains Islam Malaysia, Nilai Negeri Sembilan, Malaysia.
  • Associate Proffesor Dr. Department of Psychiatry, Pusat Perubatan Universiti Kebangsaan Malaysia, 56000 Cheras, Malaysia



Hyponatremia, Schizophrenia, indapamide, Antipsychotics


We reported a case of severe symptomatic hyponatremia with a serum sodium level of 113 mmol/l after 2 weeks commencement of 2 types atypical antipsychotics; clozapine and amisulpiride with indapamide, a thiazide-like diuretic antihypertensive medication. Discontinuation of indapamide despite of continuation of his antipsychotics showed improvement in his serum sodium level. The aim of our case-report is to emphasize the life-threatening complication associated with the combination of agents that may cause hyponatremia. Both agents are known to cause electrolytes imbalance. Hence, close monitoring of the serum sodium is important during the treatment course.


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DOI: 10.33102/mjosht.v8i.288
Published: 2022-09-21

How to Cite

Ismail, N., & Mohd Daud, T. I. (2022). Concomitant Use of Antipsychotics and Diuretic Accelerates the Hyponatremia Effect. Malaysian Journal of Science Health & Technology, 8, 28–30.